Mechanism of action of AB21®
P. acidilactici KABPTM 021
L. plantarum KABPTM 033
L. plantarum KABPTM 023
L. plantarum KABPTM 022
Lactiplantibacillus plantarum KABPâ„¢ 033 (CECT 30292)
Lactiplantibacillus plantarum KABPâ„¢ 022 (CECT 7484)
Lactiplantibacillus plantarum KABPâ„¢ 023 (CECT 7485)
Pediococcus acidilactici KABP™ 021 (CECT 7483)
immunity enhacement through a triple mechanism of action :
L. plantarum KABP™ 033
P. acidilactici KABP™ 021
L. plantarum KABP™ 022
L. plantarum KABP™ 023
Activation of the immune response through expression of PlnG, allowing direct cross-talk with immune cells
Synthesis of polyphosphate granules (poly-P), molecules that improve intestinal permeability
Production of acetate and acetylcholine, which balance the inflammatory response in the gut mucosa
Activation of the immune response allowing direct cross-talk with immune cells
Synthesis of polyphosphate granules (poly-P), molecules that improve intestinal permeability
Production of acetate and acetylcholine, which balance the inflammatory response in the gut mucosa
Immune cell stimulation
Activation of the immune response through specific gene expression, allowing direct cross-talk with immune cells. The ability to produce PlnG of several probiotic strains was tested in vitro. L. plantarum KABPâ„¢ 033 produced 4 times more PlnG than other strains, demonstrating a high ability to modulate the immune response.
Specific AB21® activity allows a cross-talk between probiotic
strains and several immunity cells,
including dendritic cells (DCs),
macrophages, monocytes and
lymphocytes.
These cells are key
players in the adaptative immune
response, activating the
production of specific
immunoglobulins (antibodies)
The capacity to boost the immune system and reach an immunological effect by a probiotic strain is quite rare and strain-specific, according to ISAPP consensus on probiotics
Enhancement of gut barrier function
When the intestinal barrier is damaged and tight junctions are faulty the gut epithelial wall allows proinflamatory substances to enter.
That is known as increased intestinal permeability
General inflammation condition increasedÂ
Polyphosphates reinforce gut epithelial tight junctions and also alleviate local inflammation
Intestinal permeability is improved, enhancing gut barrier function
Anti-inflammatory activity
Acetylcholine
Through the cholinergic anti-inflammatory pathway, acetylcholine binds to the nicotinic acetylcholine receptor α7 subunit,  inhibits the release of TNF-α and as result,  reduces inflammatory response
Acetate
Acetate is the major short-chain fatty acid (SCFA) produced by commensal bacteria in the gut. It is known to show anti-inflammatory activity, and serves as a nutrient source for epithelial cells of the mucosa
