Mechanism of action of AB21®

AB21® contains a combination of 4 selected probiotic strains with local and systemic effects on immunity

P. acidilactici KABPTM 021

L. plantarum KABPTM 033

L. plantarum KABPTM 023

L. plantarum KABPTM 022

Lactiplantibacillus plantarum KABP™ 033 (CECT 30292)
Lactiplantibacillus plantarum KABP™ 022 (CECT 7484)
Lactiplantibacillus plantarum KABP™ 023 (CECT 7485)
Pediococcus acidilactici KABP™ 021 (CECT 7483)

AB21® bacteria strains show specific properties on
immunity enhacement through a triple mechanism of action :
plantarum-destacat

L. plantarum KABP™ 033

l-plantarum

P. acidilactici KABP™ 021

4-2_q005

L. plantarum KABP™ 022

acidilactici

L. plantarum KABP™ 023

Activation of the immune response through expression of PlnG, allowing direct cross-talk with immune cells

Synthesis of polyphosphate granules (poly-P), molecules that improve intestinal permeability

Production of acetate and acetylcholine, which balance the inflammatory response in the gut mucosa

Activation of the immune response allowing direct cross-talk with immune cells

Synthesis of polyphosphate granules (poly-P), molecules that improve intestinal permeability

Production of acetate and acetylcholine, which balance the inflammatory response in the gut mucosa

Immune cell stimulation

AB21® probiotic strains, specially L. plantarum KABP™ 033, have shown to activate the immune system

Activation of the immune response through specific gene expression, allowing direct cross-talk with immune cells. The ability to produce PlnG of several probiotic strains was tested in vitro. L. plantarum KABP™ 033 produced 4 times more PlnG than other strains, demonstrating a high ability to modulate the immune response.

immune-01

Specific AB21® activity allows a cross-talk between probiotic strains and several immunity cells, including dendritic cells (DCs), macrophages, monocytes and lymphocytes.
These cells are key players in the adaptative immune response, activating the production of specific immunoglobulins (antibodies)

The capacity to boost the immune system and reach an immunological effect by a probiotic strain is quite rare and strain-specific, according to ISAPP consensus on probiotics

Enhancement of gut barrier function

AB21® strengthens the gut barrier and decreases local inflammation thanks to the production of polyphosphates

When the intestinal barrier is damaged and tight junctions are faulty the gut epithelial wall allows proinflamatory substances to enter.

That is known as increased intestinal permeability

General inflammation condition increased 

Polyphosphates reinforce gut epithelial tight junctions and also alleviate local inflammation

Intestinal permeability is improved, enhancing gut barrier function

Anti-inflammatory activity

AB21® promotes the production of two molecules that balance the inflammatory response

Acetylcholine

Through the cholinergic anti-inflammatory pathway, acetylcholine binds to the nicotinic acetylcholine receptor α7 subunit,  inhibits the  release of TNF-α and as result,  reduces inflammatory response

Acetate

Acetate is the major short-chain fatty acid (SCFA) produced by commensal bacteria in the gut. It is known to show anti-inflammatory activity, and serves as a nutrient source for epithelial cells of the mucosa